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Titlebook: Health Risk Assessment of Environmental Chemicals; Pre-Emptive and Inte Masami Ishido Book 2023 The Editor(s) (if applicable) and The Autho

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Endocrine Disruptorson of endocrine-disrupting chemicals (endocrine disruptors) is the same, since their kinetics is nonmonotonic. In this chapter, it is shown how the endocrine disruptors kinetically work and how to regulate the concentration for daily uptake.
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Fields and Exposure Periodshe target tissues. Also, it is shown that toxicity is dynamic such as from peripheral to central organs, which leads to the idea of pre-emptive and integrated approaches for health risk assessment of environmental chemicals.
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Environmental Chemicals as Plasticity Disruptorsas well as brain plasticity. Environmental chemicals often disrupt developmental plasticity, leading to adult disease onset. It is explained by the hypothesis of DOHaD (Developmental Origins of Health and Disease) proposed by Dr. Baker.
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Integration of Health Risk Assessment for Various Chemicals: Common Biomarkers in Different Exposuresed by not only endocrine disruptors but also pesticides, nanoparticles, carcinogenic chemicals, and air pollutants. These suggest that rat hyperactivity is related to neither chemical structure nor exposure routes. There may be a common sensor in dopaminergic systems to integrate various branch tox
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