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Titlebook: Handbook on Immunosenescence; basic understanding Tamas Fulop,Claudio Franceschi,Graham Pawelec Book 2009 Springer Science+Business Media

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书目名称Handbook on Immunosenescence
副标题basic understanding
编辑Tamas Fulop,Claudio Franceschi,Graham Pawelec
视频video
概述The first comprehensive handbook on immunosenescence.First to treat in one volume all the aspects of immunosenescence.Bridging bench research and clinical applications.Written by internationally recog
图书封面Titlebook: Handbook on Immunosenescence; basic understanding  Tamas Fulop,Claudio Franceschi,Graham Pawelec Book 2009 Springer Science+Business Media
描述.“Immunosenescence” is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metaboli
出版日期Book 2009
关键词Antigen; Immunosenescence and clinical applications; Thymus; aging; cancer; frailty; infections; metabolic
版次1
doihttps://doi.org/10.1007/978-1-4020-9063-9
isbn_softcover978-94-017-7721-6
isbn_ebook978-1-4020-9063-9
copyrightSpringer Science+Business Media B.V. 2009
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Insect Models of Immunosenescencee response. In addition, recently completed genome sequences of invertebrates (e.g., . : C. elegans Sequencing Consortium 1998 ; . : Adams et al. 2000 ; . : Holt et al. 2002 : . : Xia et al. 2004 ) reveal that many of the genes regulating the innate immune response have homologous genes in vertebrat
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Clonal Culture Models of T-cell Senescencenal levels, and to test interventions of possible clinical utility. This chapter describes techniques for the production and maintenance of human TCC in vitro, the impact of culture conditions and oxygen levels on lifespan, and the application of genomic and proteomic analyses in this model.
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Age-related Changes in Subpopulations of Peripheral Blood Lymphocytes in Healthy Japanese Populationthese immunological parameters was steeper in females than in males ( . <0.05). The T-cell proliferation index (TCPI), which was calculated based on T-cell proliferative activity and the number of T-cells, showed an age-related decline. The rate of decline in the TCPI was again steeper in males than
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Mismatch Repair System and Aging: Microsatellite Instability in Peripheral Blood Cells of the Elderlair System that is recently emerging as a possible additional mechanism contributing to the accumulation of genetic instability during aging in peripheral blood cells. In vivo data at present available in the literature and results from studies on cloned human T lymphocytes cultured for different pe
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