Titlebook: Handbook of the Cerebellum and Cerebellar Disorders; Mario U. Manto,Donna L. Gruol,Roy V. Sillitoe Reference work 2022Latest edition Sprin

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Synaptogenesis and Synapse Eliminationproximal portion of the dendrite, and they are eliminated progressively during the second and the third postnatal weeks. From around P7 to P11, the elimination proceeds independently of the formation of the synapses on PC dendrites from parallel fibers (PFs), the other excitatory afferents to PCs. F

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Hormones and Cerebellar Developmentfunctional impairment. Estrogen and progesterone also play important roles in this process. In addition to the supply from circulation, several gonadal steroids are produced locally within the Purkinje cells (neurosteroids). This chapter discusses the effect of thyroid and steroid hormones on cerebe

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Development of Physiological Activity in the Cerebellumst changes in synaptic and intrinsic activity may be common developmental changes contributing to the pathophysiology of not only cerebellar ataxias but also neurodevelopmental diseases such as autism spectrum disorders. Finally, we posit that these findings support a hypothesis for an important rol

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Handbook of the Cerebellum and Cerebellar Disorders

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Reference work 2022Latest editionlar in the field of genetic ataxias. More than 20 new genes have been identified these last 10 years. Only for dominant ataxias, more than 30 diseases have now been unravelled. The number of ataxic disorders will increase with aging, the cerebellum being the structure of the brain with the most impo

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