Titlebook: Handbook of Psychopharmacology; Volume 20 Psychophar Leslie L. Iversen,Susan D. Iversen,Solomon H. Snyd Book 1988 Plenum Press, New York 19

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,Chemical Neuroanatomy of Alzheimer’s Disease,) plaques (NP) and neurofibrillary tangles (NFT). The NFT, which can be visualized by silver staining or by the fluorescent thioflavin-S stain, is an accumulation of fibrillary material that originates within neuronal cell bodies. As the neurofibrillary material accumulates (see Fig. 1), it graduall

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,Dementia in Parkinson’s Disease,nifestations, but more recently, as neurochemical data accumulate, on a more fundamental biological level. It has become traditional to begin discussion of this subject with the remark that James Parkinson (1817) explicitly excluded intellectual deterioration from the clinical picture of the disease

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,Alzheimer’s Disease: Genetic Theories of Etiology,nowledge of the underlying structural and chemical . of the disease process (much of it summarized elsewhere in this volume). But disappointingly little is known about ., the causes of these changes. Epidemiological studies of AD have revealed only one firmly established risk factor (apart from age)