Titlebook: Handbook of Oncobiology: From Basic to Clinical Sciences; R. C. Sobti,Nirmal K. Ganguly,Rakesh Kumar Reference work 2024 Springer Nature

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History, Evolution, and Milestones in Cancer Research and Treatmentd therapy have definitely enhanced not only the survival rate but also the quality of life of cancer patients. In present times, genetic engineering studies have amplified the further advancements of cancer biology by utilizing monoclonal antibodies and immune checkpoint inhibitors specifically for

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Advancement in Cancer Modeling System: Latest Developments and Trends in Cancer Research and Healthcer indicators and targeted medicines, and they are particularly useful in drug development. The promise of cancer models as a vehicle for drug screening and therapeutic advances is underlined in this chapter. Although none of the cancer models can be considered ideal since each has important limitat

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Mechanisms of Oncogenesisignals, ribosomal stress, psychological stress signals, and oncogenic activation. Genotoxic stress signals including radiations cause DNA damage resulting in activation of ATM and ATR genes. DNA damage signaling and double strand break repair by homologous recombination, mRNA splicing, and microRNA

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Genetic Alterations and Microbial Dysbiosis Underlie Lymph Node Metastasis in Tongue Cancern-homologous end-joining (NHEJ) and homologous recombination (HR) pathways, hotspot mutations in genes such as TP53 and CASP8, and the potential utility of MMP10 as a biomarker. Additionally, microbial signatures, such as the 30-feature bacterial signature in oral cancer and miRNA signatures related

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