Titlebook: Handbook of Electroporation; Damijan Miklavčič Reference work 2017 Springer International Publishing AG 2017 nanosecond pulsed electropora

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https://doi.org/10.1007/978-1-349-08243-8many applications, including the delivery of genes and drugs into cells, as well as tumor ablation. Understanding the nature of pores, including size and resealing properties, under various EP exposure conditions is essential for various applications of biomedicine and biotechnology. To better under

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Cynthia Bonville,Joseph Domachowskeunilamellar vesicles with sizes in the range of tens of microns. Because of their large size, the response of the membrane to electric fields can be directly visualized under the microscope. The membrane behavior is exemplified by several types of responses: First, the vesicles undergo morphological

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Vaccines as Social and Political Phenomena?, application of pulsed electric field (.) leads to the partial permeabilization of the cell membrane, opening access to the cytoplasmic compartment for drug delivery, for instance. The electric impedance of the cell is modified by such a treatment. Impedance measurement can thus be employed to chara

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Lipid Pores: Molecular and Continuum Modelsrane transport of drugs, genetic material, and other molecules. The full details of the molecular mechanisms, which lead to the increased membrane permeability, are not yet entirely clear. However, extensive theoretical and experimental studies on model lipid systems demonstrated that formation of a

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Phospholipid Head Group Dipoles and Electropore Formationiseconds. The field intensity is large enough to induce a dramatic structural local alteration of the cell membrane organization. This results in an enhanced permeabilization of the target cell membrane. This is indeed a complex process and its molecular characterization remains an intense field of