Titlebook: Handbook of Chemical Biology of Nucleic Acids; Naoki Sugimoto Living reference work 20220th edition DNA.RNA.Riboswitch.Ribozyme.Quadruple

漂白

,Einige zusätzliche Aphorismen, have also advanced as pivotal tools in numerous applications such as therapeutic technologies, diagnostics, or material sciences. Chemical modifications, particularly at the level of the nucleobases, are ubiquitous. Indeed, base modifications in natural DNA and RNA are nearly as important as the pr

tenosynovitis

Lobotomy

Stability Prediction of Canonical and Noncanonical Structures of Nucleic Acids,y used in various technical applications using nucleic acids. Thermodynamics for the structural changes is highly useful and important for understanding the biological mechanism of nucleic acid function, as well as for the design of materials for nucleic acids. The canonical structure of nucleic aci

诱骗

The Effect of Pressure on the Conformational Stability of DNA,ze the canonical and noncanonical DNA structures. Under most solution conditions, double- and triple-stranded DNA molecules are stabilized to a small extent by increasing pressure regardless of their nucleotide sequence. On the other hand, the stabilities of noncanonical conformations, including hai

BOLUS

Vulnerary

NMR Study on Nucleic Acids,biochemical studies. Knowledge of the structure and dynamics of nucleic acids is important not only for understanding biological mechanisms, but also for developing new therapeutics. NMR (Nuclear Magnetic Resonance) spectroscopy has been used for many years to determine the structure of nucleic acid

全神贯注于

Z-DNA,eral Z-DNA-binding proteins and Z-DNA-forming sequences in the genome have confirmed the biological relevance of Z-DNA. Over the last five decades, enormous scientific achievements have been made by outstanding scientists to reveal the chemical nature of Z-DNA and the role of Z-DNA and Z-DNA-binding

Moderate

刚开始

In Cell 19F NMR for G-quadruplex,area of research in telomere, gene regulation, and functional genomics research. Investigation of G-quadruplex structures associated with biological events is therefore essential to understanding the functions of these molecules. Antibodies and some small molecules have been used to investigate DNA

河流

Structures and Catalytic Activities of Complexes Between Heme and DNA,raction between them at the atomic level is expected to provide valuable information for revealing the molecular mechanism responsible for the regulation of diverse biological processes through their interaction. Heme binds selectively to the 3’-terminal G-quartet of a parallel G-quadruplex DNA to f