Titlebook: Handbook of Chemical Biology of Nucleic Acids; Naoki Sugimoto Reference work 2023 Springer Nature Singapore Pte Ltd. 2023 DNA.RNA.Riboswit

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Predicting the 3D Structure of RNA from Sequencectures that they form are essential for the performance of their functions. Experimentally determining the 3D structure of an RNA molecule is difficult and time consuming, so it is desirable to be able to predict the 3D structure that an RNA molecule will fold into based only on the molecule’s seque

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Hexitol Nucleic Acid (HNA): From Chemical Design to Functional Genetic Polymerherapeutic agents to modulate gene expression or impede protein function by binding a specific RNA sequence or target protein but also in synthetic biology, particularly in the context of artificial genetic polymers (XNAs). In order to enable maximum scope for all . applications, it is pivotal for o

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The Effects of FANA Modifications on Non-canonical Nucleic Acid Structurescations in structure elucidation, synthetic genetics, and therapeutics, among others. This chapter explores the use of 2′-fluoroarabino nucleic acids (FANA) in the context of noncanonical nucleic acid structures, namely triple helices, G-quadruplexes, and i-motifs. For the last three decades, FANA h

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Isomorphic Fluorescent Nucleoside Analogs nucleosides present enormous opportunities. Here we discuss their fundamental design features, compare and contrast them to other families of fluorescent nucleoside analogs, as well as illustrate their utility and highlight potential limitations. The isomorphic nature of the analogs and their faith

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https://doi.org/10.5822/978-1-61091-904-3y used in various technical applications using nucleic acids. Thermodynamics for the structural changes is highly useful and important for understanding the biological mechanism of nucleic acid function, as well as for the design of materials for nucleic acids. The canonical structure of nucleic aci

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Traité de nutrition artificielle de l‘adulteences via hemi-protonated and intercalated C·C. base pairs. Although this structure is favored at acidic pH, recent evidence has demonstrated its existence in vivo, stimulating the exploration of its biological roles. Before that, it was mostly regarded as a mere structural oddity, or a tool for bio