Titlebook: Handbook of Cancer Vaccines; Michael A. Morse,Timothy M. Clay,H. Kim Lyerly Book 2004 Springer Science+Business Media New York 2004 Antige

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https://doi.org/10.1007/978-981-99-9647-6demonstrated activity in renal cell carcinoma and melanoma. In the past two decades, a new era in cancer immunotherapy has opened with the discovery of how the immune system can recognize and destroy tumors. This has included the description of tumor-expressed antigens that can be recognized by immu

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Palpable

School-Related Inequity Factorss such as antibody and T cells from cancer patients. Genes identified via this integrated approach have the advantage of being tumoror tissue-specific and broadly expressed in cancers. Numerous tissue- and tumor-specific genes have been identified in prostate, breast, lung, and colon cancers using t

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Toward Integrative Corporate Citizenshipge colony-stimulating factor (GM-CSF), or tumor necrosis factor-α (TNF-α) in response to human leukocyte antigen (HLA)-matched tumor targets. Tumor-reactive class II restricted T cells have also been identified in a significant percentage of the cultures of sensitized PBMC or TIL cultures containing

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The Necessary Forms of the Knowledger human tumors to escape the immune system. In addition, current evidence supports a model by which this active tumor-mediated immunosuppression is largely the result of secretion of the potent immunosuppressive cytokine, transforming growth factor-ß (TGF-ß). In this review, the evidence supporting

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https://doi.org/10.1057/9780230119819immunization to foreign proteins normally elicits immunity to only a subset of potential epitopes, dominant epitopes, whereas other potentially immunogenic epitopes, subdominant epitopes, are ignored. There is evidence that T cells are tolerant to the dominant epitopes of self-proteins, but may resp

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Improving the Quality of Urbanization,py is the ideal time for immune intervention, and in particular for administration of cancer vaccines aimed at instructing the immune system to identify and kill these few remaining cancer cells. If antibodies of sufficient titer can be induced against tumor antigens to eliminate tumor cells from th

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