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Titlebook: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics; William D. Figg,Howard L. McLeod Book 20041st edition Humana Press 2004 DNA.

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书目名称Handbook of Anticancer Pharmacokinetics and Pharmacodynamics
编辑William D. Figg,Howard L. McLeod
视频videohttp://file.papertrans.cn/421/420813/420813.mp4
概述Includes supplementary material:
丛书名称Cancer Drug Discovery and Development
图书封面Titlebook: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics;  William D. Figg,Howard L. McLeod Book 20041st edition Humana Press 2004 DNA.
描述Leading investigators synthesize the entire laboratory and clinical process of developing anticancer drugs to create a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including clinical trial design, preclinical screening, and the development and validation of bioanalytic methods. The chapters on identifying agents to test in phase III trials and on trial design for the approval of new anticancer agents offer a unique roadmap for moving an agent to NDA submission.
出版日期Book 20041st edition
关键词DNA; angiogenesis; cancer; clinical trial; cytochrome P450; drug discovery; drug resistance; gene therapy; k
版次1
doihttps://doi.org/10.1007/978-1-59259-734-5
isbn_ebook978-1-59259-734-5Series ISSN 2196-9906 Series E-ISSN 2196-9914
issn_series 2196-9906
copyrightHumana Press 2004
The information of publication is updating

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Mouse Models in Cancer Drug Discovery and Development,l proliferation either in tissue culture (in vitro) or in animals (in vivo), without specific reference to a molecular or cellular target of action. Indeed, the potentially useful effects of the vast majority of agents currently approved for use as safe and effective as oncologic therapeutics in hum
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Pharmacokinetic Modeling,s usually limited to the blood or plasma. Pharmacokinetic data analysis consists of examining plasma concentration—time data and estimating pharmacokinetic parameters that describe drug disposition. Methods used for pharmacokinetic analysis include noncompartmental analysis or pharmacokinetic modeli
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Protein Binding of Anticancer Drugs,incingly for several important drugs .. Such tests generally are not appropriate for drugs of limited effectiveness and potency and in patients who respond well to the usual dosage regimen of a drug. They are also superfluous for drugs whose intensity of action can be judged accurately during their
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