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Titlebook: HIV and Dementia; Proceedings of the N Michael B. A. Oldstone,Ljubiša Vitković (Chief, Ne Conference proceedings 1995 The Editor(s) (if app

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书目名称HIV and Dementia
副标题Proceedings of the N
编辑Michael B. A. Oldstone,Ljubiša Vitković (Chief, Ne
视频videohttp://file.papertrans.cn/421/420207/420207.mp4
丛书名称Current Topics in Microbiology and Immunology
图书封面Titlebook: HIV and Dementia; Proceedings of the N Michael B. A. Oldstone,Ljubiša Vitković (Chief, Ne Conference proceedings 1995 The Editor(s) (if app
描述The National Institute of Mental Health (NIMH) AIDS Program is the fourth largest acquired immune deficiency syndrome (AIDS) program within the National Institutes of Health (NIH). Since 1983, our program‘s contributions have concentrated on two major areas. The first has been to develop effective strategies to prevent or reduce behaviors that place individuals at risk for human immunodeficiency virus type 1 (HIV-1) infection. The second has been to support and foster research to enhance our understanding of the profound impact of H IV-1 infection on the central nervous system (eNS). The brain appears to be a prime target of the virus and may serve as a reservoir for the virus. Post mortem examination of brain tissue has provided evidence of eNS cell damage in 80%-90% of people who die with AIDS. For about 10%-20% of people with AI DS, mild neuropsychological symptoms are the first signs of the disease. Approximately 20% of individuals infected with HIV-1 develop AIDS dementia complex. The symptoms include apathy, difficulty concentrat­ ing, irritability, depression, and personality changes. In the later stages of the disease, people may experience psychiatric disor­ ders. Death us
出版日期Conference proceedings 1995
关键词AIDS; HIV; brain; cognition; cytokine; dementia; immunodeficiency; infection; nervous system; neurobiology; ne
版次1
doihttps://doi.org/10.1007/978-3-642-79657-9
isbn_softcover978-3-642-79659-3
isbn_ebook978-3-642-79657-9Series ISSN 0070-217X Series E-ISSN 2196-9965
issn_series 0070-217X
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE
The information of publication is updating

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Michael B. A. Oldstone,Ljubiša Vitković (Chief, Ne
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https://doi.org/10.1007/978-1-4757-6738-4 from an overall slowing of mentation. In addition to slowness of thought and motor activity, a variety of behavioral abnormalities have been noted (. et al. 1987). The dementia associated with AIDS was thus unlike the well described cortical dementias such as Alzheimer’s disease, notable for aphasi
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https://doi.org/10.1007/978-3-031-37200-1ted by activation of one family of glutamate receptors (. 1992). Glutamate is the major excitatory neurotransmitter in the brain. Glutamate receptor-mediated neuronal death—excitotoxicity—is implicated in the pathogenesis of several disorders affecting mental health such as Alzheimer’s dementia (. 1
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https://doi.org/10.1057/9781137018908t the way to effective therapeutic intervention. In the absence of definitive views of viral pathogenesis, we must rely on basic knowledge about how virus structure and unique features of the viral life cycle can be exploited for the development of effective therapeutic agents.
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Neil A. R. Gow,Geoffrey M. Gaddof membrane components as well as the differential targeting of distinct sets of lipids and proteins to apical vs basolateral membranes, the epithelial cells in such tissues are highly polarized, with each plasma membrane domain having a distinct lipid and protein composition (reviewed by . and . 19
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