Titlebook: HIV and Dementia; Proceedings of the N Michael B. A. Oldstone,Ljubiša Vitković (Chief, Ne Conference proceedings 1995 The Editor(s) (if app

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https://doi.org/10.1007/978-3-540-85207-0 viruses to human suffering has escalated enormously, and forecasts suggest that this will increase in the years to come. At present of course there is no vaccine for HIV, and this drives much of the current effort to molecularly dissect the antiviral immune response.

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0070-217X concentrat­ ing, irritability, depression, and personality changes. In the later stages of the disease, people may experience psychiatric disor­ ders. Death us978-3-642-79659-3978-3-642-79657-9Series ISSN 0070-217X Series E-ISSN 2196-9965

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Penetration of Solutes, Viruses, and Cells Across the Blood-Brain Barriersicles (. and . 1967). The junctions, being zonular, seal the intercellular cleft, thereby preventing movement of solutes from blood into CNS extracellular fluid and from interstitial fluid into blood (. and . 1968). Smaller hydrophilic molecules such as heme-peptide, about 2 kDa in size, are also e

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Distinct HIV-1 , Sequences Are Associated with Neurotropism and Neurovirulencethe gray matter of the spinal cord and brain stem. In contrast, FMCF-98D murine retrovirus (. et al. 1990) causes an ataxic disease associated with infection of white matter tracts of the cerebellum but showing minimal pathology. Friend TR 1.3 induces a stroke-like syndrome secondary to infection of

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Therapeutic Approaches to HIV Infection Based on Virus Structure and the Host Pathogen Interactiont the way to effective therapeutic intervention. In the absence of definitive views of viral pathogenesis, we must rely on basic knowledge about how virus structure and unique features of the viral life cycle can be exploited for the development of effective therapeutic agents.

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