| 书目名称 | HCV Infection and Cryoglobulinemia | | 编辑 | Franco Dammacco | | 视频video | | | 概述 | Comprehensive review of cryoglobulinemia, for scientists and specialists involved in several disciplines, including internal medicine, hepatology, hematology, oncology, infectious diseases, rheumatolo | | 图书封面 |  | | 描述 | The first observation of cold-induced precipitation of serum proteins dates back to 1933, when Wintrobe and Buell first described an unusual case of multiple myeloma in a woman whose serum reversibly precipitated at cold temperatures. In 1947 Lerner and Watson showed cold-precipitable proteins to be gammaglobulins and called them ‘cryoglobulins’ and the corresponding clinical condition ‘cryoglobulinemia’. Meltzer and Franklin in 1966 provided an accurate description of the typical clinical symptoms associated with cryoglobulinemia, showed that they consisted of two different globulin components and, because of the ignorance on its etiology, called this clinical condition ‘essential mixed cryoglobulinemia’. For almost 20 years progress has been rather slow in this field, but when at the end of the ‘80s it finally became possible to detect the occurrence in the serum of antibodies to the hepatitis C virus (HCV), many groups in Europe and the United States almost simultaneously reported that a high proportion of ‘essential’ cryoglobulinemias are in fact associated with HCV infection. This hallmark has resulted in a new impetus and great enthusiasm in carrying out new researches made p | | 出版日期 | Book 20121st edition | | 关键词 | Autoimmunity; Cryoglobulinemia; HCV; Immune Complex Diseases; Malignant Lymphoma; hepatology; infectious d | | 版次 | 1 | | doi | https://doi.org/10.1007/978-88-470-1705-4 | | isbn_softcover | 978-88-470-5581-0 | | isbn_ebook | 978-88-470-1705-4 | | copyright | Springer-Verlag Italia 2012 |
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发表于 2025-3-21 19:16:26
