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Zur Funktion der Chorpartien in den ,eficits. CP encompasses various movement- and posture-related disorders, often accompanied by cognitive, behavioral, and sensory disruptions, as well as epilepsy and musculoskeletal issues. The CP classification is gauged by the severity of motor function impairment and the dominant movement disorde
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https://doi.org/10.1007/978-90-368-0788-3spasticity for more than 50 years. After the promising results of preclinical studies suggesting a potential role of baclofen in the treatment of alcohol use disorder (AUD), several randomized controlled trials (RCTs) have been conducted to evaluate its safety, tolerability, and efficacy in people w
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Sprachaneignung bei Geflüchtetensfunction associated with the receptor function has been linked to various diseases and neuropsychiatric disorders, making it a highly relevant drug target over the past decades. Traditionally, drug discovery campaigns targeting the GABA. receptor have focused on the discovery and development of lig
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https://doi.org/10.1007/978-3-642-01616-5ession, anxiety, epilepsy, chronic pain, autism, and substance use disorders, among others. In this direction, a number of GABA. receptor agonists were developed, one of which, baclofen, has been approved for clinical use for the treatment of muscle spasms related to multiple sclerosis and spinal co
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https://doi.org/10.1007/978-3-322-86250-1or use in the treatment of a series of brain disorders, including substance use disorder (SUD). This chapter describes the current state of preclinical findings on (i) the interaction of drugs of abuse and GABA. receptors in the brain and signaling pathways and (ii) the effects of GABA. PAMs in seve
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