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Clinical Applications of Drug Studiesns. Superimposed on these variations arc the many complex factors which govern drug response. To complicate matters further, it has recently been hypothesized that long-term drugs may induce brain changes which lead to manifestations perhaps indistinguishable from the symptoms of the original illness.
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Neuroregulators and Schizophrenia: A Look at the Dopamine and Endorphin Hypothesesful and generally accepted notion of that disorder—yet the hypothesis remains unproven and can be reformulated to take into account recent concepts regarding the physiology of the dopaminergic neural unit as it can be described mathematically. The other system is the opioid peptide system, really a
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