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Serum and Urinary Guanidino Compounds in “Sparse-Fur” Mutant Mice with Ornithine Transcarbamylase Denked ornithine transcarbamylase (OTC) (E.C.:2,3.1.3.) deficiency. Normal CD-l/Y males were used as controls. The results indicate no significant differences in the serum guanidinosuccinic acid (GSA) values between spf/Y (0.34 ± 0,06µM) (mean ± SEM) and CD-l/Y (0.28 ± 0.02), or its urinary excretion

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Biosynthesis of 2-Guanidinoethanolatography-mass spectrometryl. GEt was also observed to be excreted in urine of vertebrates like rabbits, mice, rats and cats.. Previously, we reported that ethanolamine (EA) is a precursor of GEt biosynthesis in intact mice and that GEt is synthesized from Arg and EA by a transamidination reaction i

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The Existence of Multiple Forms of Rat Kidney Transamidinase other than their separation from each other by chromatography on DEAE cellulose. Polyclonal antibodies made to the .-form of the enzyme reacted with the β-form of the enzyme and precipitated all of the enzyme activity from a rat kidney homogenate. The low transamidinase activities in kidneys from r

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Active Oxygen in Methylguanidine Synthesis by Isolated Rat Hepatocytes.. Chemically, MG is an oxidative product which results from the exposure of creatinine (CRN) to silver, mercury, copper, Fe. or charcoal.. However the factors affecting the oxidation of CRN to MG are far different from the internal environment of uremics, and the mechanism of its synthesis . still

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The Reactivity of Guanidino Compounds with Hydroxyl Radicalsdinoglutaric acid. and homoarginine., which are detected in the mammalian brain, induce epileptic discharges and/or induce convulsions after intracisternal injection or local administration into the rodent cortex. The seizure mechanisms are still unclear.

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Dimethylarginine has Digitalis-Like Activity-ATPase (ATP phosphohydrolase, EC 3.6.1.3)-inhibiting activity, plays an important role in the pathogenesis of essential hypertension.. It was also reported that in human urine there were two natriuretic substances with the molecular weight of greater than 30,000 and smaller than 3,000., and that th

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