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https://doi.org/10.1007/978-3-322-99573-5EGF can cooperatively induce the additive enhancement ofliver regeneration through an increase in Ras/MAPK activity followed by cyclin D. expression, and that TGF-ß. suppresses the growth factor-induced signals between cyclin D. and cyclin E, resulting in inhibition of DNA synthesis.

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https://doi.org/10.1007/978-3-663-11085-9signaling, especially SRE-, AP-1-, NF-κB-, and pS3-associated pathways. Core protein activated IL-8 promoter through NF-κB and AP-1 and activated p21 promoter having a pS3-binding site. Core protein activated the NF-κB pathway mainly through IKKß and tumor necrosis factor receptor-associated factor

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Reconstitution of Hepatic Tissues Using Liver Stem Cells,ransplantation and an artificial liver to replace liver transplantation is urgently needed. Some clinical applications have been attempted with unsatisfactory results. In the future, it will be necessary to establish more effective therapy by incorporating tissueengineering techniques to construct h

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Signal Transduction Involved in Cell Cycle Regulation of Normal Hepatocyte and Hepatoma Cells,induced and modulated by signal transduction governing cell growth and differentiation. We found that when normal rat hepatocyte growth was induced by hepatocyte growth factor (HGF), HGF receptor (MET) was activated, with association of MET with growth factor receptor-bound protein (GRB)-2, which is