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Epidermal Growth Factor: Biology and Properties of its Gene and Protein Precursorirst isolated in the early 1960s from murine submaxillary glands by Stanley Cohen (1962). EGF stimulates the proliferation of epidermal and epithelial cells in whole animals and of a variety of cell types in culture (Carpenter and Cohen 1979). A number of early biochemical changes occur after bindin
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Platelet-Derived Growth Factor: Formation and Biological Activities82) made up of three combinations of two disulfide-bonded chains, denoted the A and B chains. PDGF binds to two distinct but closely related PDGF receptors, termed a- and β-receptors (Yarden et al. 1986; Gronwald et al. 1988; Matsui et al. 1989). The predominant biological role of PDGF is to stimula
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Basic Fibroblast Growth Factor: Properties and Clinical Implications3T3 cells, an established mouse fibroblast cell line (Gospodarowicz et al. 1987). The mitogen was therefore termed basic fibroblast growth factor (bFGF). The initial purification procedures were cumbersome and time consuming. A major breakthrough was achieved in 1984 with the introduction of heparin
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Distinctive Features of Nerve Growth Factor: Structure, and Function neuronal populations. Nerve growth factor (NGF) still serves as the only example of a neurotrophic factor whose physiological role is firmly established. Although the the actions of NGF were originally thought to be restricted to the sympathetic and neural crest derived sensory neurons, it is clear
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Interleukin 1ogical properties. The term interleukin 1 was introduced in 1979 (Aarden et al. 1979) to describe a product of . that stimulated T cells and B cells but also had non-immunological properties. In contrast, interleukin-2 refers to the . product with T-cell stimulating properties.
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Interleukin 2ion grafts. T-lymphocytes act as helper/inducer cells for effector T cells, B cells, macrophages, and others. Many of these functions are due to the secretion of lymphokines by activated T cells. The most prominent lymphokine so far is interleukin 2 (IL-2) which was first described in 1976 as T-cell
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Interleukin 3: A Multilineage Hematopoietic Growth Factor rather supports the survival, stimulates the proliferation, and directs the differentiation of pluripotent stem cells and committed precursors in the myeloid (including erythroid) compartment. The major advances in the study of the growth and differentiation of the hematopoietic system have relied
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