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Fibroblast Growth Factors as Local Mediators of Gonadal Functionunction remains, to a large extent, speculative. The main reason behind this problem is the fact that in in vitro assays, growth factors have a tremendous number of biological activities. A case in point is basic fibroblast growth factor, basic FGF (3,4). This mitogen is characterized by its ability

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The Role of Insulin-Like Growth Factors in Granulosa Cell Steroidogenesis: Studies with a Neutralizivarian regulators. To further assess the role of these peptides in ovarian function, we have employed a neutralizing monoclonal antibody to IGF-I to block the actions of IGFs in porcine follicular fluid and in granulosa cell-conditioned medium. Granulosa cells from immature porcine follicles were cu

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