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https://doi.org/10.1057/9781137005908ost. They inevitably participate in reactions occurring on cell membranes and in the fluid phase of the interstices. Structural alterations and the local or systemic change in their concentration, induced by internal or external factors, and the concomitant emergence of new compounds, represent the
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Gram-Negative Bacteria: The Determinants of Pathogenicityo inhibit host defence mechanisms; and 4. ability to damage the host. The general methods for investigating the determinants of microbial pathogenicity and the difficulties encountered have been described (48) and will not be re-iterated here.
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Changes and Present Status of Resistance to Antimicrobial Drugs in Gram-Negative Bacteriaes, by regrouping of the local spectrum of pathogens, or by acquisition of resistance factors. This is especially true for many of the gram-negative bacteria which are well-known as microbes with a high potential for increasing resistance to antibiotics. In order to obtain results of common interest
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