Titlebook: Gossypol; A Potential Contrace Sheldon J. Segal Book 1985 Plenum Press, New York 1985 assessment.cell.heart.leukemia

治愈

The Arrhythomogenic Effect of Gossypol in the Rat Heartnsive, but it has some reported side effects, one of which is cardiac arrhythmias. Gossypol has been at least circumstantially associated with sinus bradycardia, bundle branch block, premature beats, and ventricular fibrillation in some patients and experimental animals [3, 4, 5, 6, 7, 8]. However,

endocardium

Synchronism

A Reproduction and Teratology Study with Gossypolin various species: rats [2, 3, 4, 5], mice [6], hamsters [7, 8, 9], rabbits [10, 11], and monkeys [12]. Differential susceptibility among species exist: hamsters appear to be the most susceptible and mice and rabbits the least susceptible to the antifertility effects of gossypol [13, 14, 15]. The p

AVID

Effect of Gossypol on Prostatic Androgen Receptors in Male Ratsed to be 98.4% effective [1]. Apart from some preliminary observations, the precise mechanism of action of gossypol is not clear. It has been reported that it inhibits testosterone production in the rats [2] and impairs accessory sex organs function in mice and rats [3, 4]. Chinese researchers have

opinionated

Effect of Gossypol on Accumulation of Rhodamine-123 by Sertoli Cell Mitochondriafertility effect is reversible and reportedly not detrimental to nonreproductive organs, providing the subjects’ protein and iron intake are adequate [1, 2, 3, 4]. Gossypol is neither mutagenic when assessed by the Ames test [5], nor does it cause chromosomal aberrations [6, 7].

MEEK

Magnificent

Evaluation of Gossypol’s Effect on Bull Spermatozoa in Vitro this inhibition is not known, it is clear that gossypol inhibits the activities of certain enzymes involved in the metabolic regulation of spermatozoa. The major enzymes reported to be affected by gossypol treatment are ATPase [4], lactic dehydrogenase and LDH-X [5, 6]. These enzymes are associated

灾难

Influence of Gossypol on the Motility and Dynein ATPase Activity of Sea Urchin Spermy organs [5], resulting in a reduction of sperm count, have all been demonstrated, as has its capacity to inhibit. the motility of spermatozoa of various species, including that of human beings [6, 7], other mammals [8], and even sea urchins [9, 10]. Gossypol interacts with various macromolecules su

PATHY

蚊子

Biochemical Studies of Gossypolm of action will be essential, since such elucidation may lead to the development of synthetic compounds exhibiting the desired antifertility effect without the toxicity so far noted in animals and in humans.