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Titlebook: Gossypol; A Potential Contrace Sheldon J. Segal Book 1985 Plenum Press, New York 1985 assessment.cell.heart.leukemia

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https://doi.org/10.1007/978-3-7091-3274-6hondrial enzymes, Mg. and Na., K.-dependent ATPases and pyruvate dehydrogenase [2], to a suppression in the transport of ATP to the sperm’s motility apparatus [3] and to an inhibition of dynein ATPase [4].
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,Maßsysteme und maßtechnische Daten,m of action will be essential, since such elucidation may lead to the development of synthetic compounds exhibiting the desired antifertility effect without the toxicity so far noted in animals and in humans.
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Effect of Gossypol on Accumulation of Rhodamine-123 by Sertoli Cell Mitochondriafertility effect is reversible and reportedly not detrimental to nonreproductive organs, providing the subjects’ protein and iron intake are adequate [1, 2, 3, 4]. Gossypol is neither mutagenic when assessed by the Ames test [5], nor does it cause chromosomal aberrations [6, 7].
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Binding of [,C]Gossypol by, Spermhondrial enzymes, Mg. and Na., K.-dependent ATPases and pyruvate dehydrogenase [2], to a suppression in the transport of ATP to the sperm’s motility apparatus [3] and to an inhibition of dynein ATPase [4].
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Gerhard Sielhorst,Manuela WilhelmGossypol has been shown to uncouple oxidative phosphorylation [1] to inhibit adenosine triphosphatase [2, 3], and lactodehydrogen- ase-X [4, 5], and to cause degeneration of mitochondria and sperm flagella [6].
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978-1-4612-9729-1Plenum Press, New York 1985
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