| 书目名称 | Gold-Catalyzed Cycloisomerization Reactions Through Activation of Alkynes |
| 副标题 | New Developments and |
| 编辑 | Antoine Simonneau |
| 视频video | |
| 概述 | Nominated as an Outstanding Ph.D. thesis by Université Pierre et Marie Curie, France.Establishes higher molecular complexity in products of new gold catalyzed cyclization reactions and follow-up chemi |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | Antoine Simonneau‘s thesis highlights the development of new cycloisomerization reactions through the activation of alkynes with gold complexes. First Simonneau describes 1,6-enynes and their direct conversion into allenes through 1,5-hydride or ester migration processes. The author and his team used appropriate propargylic functional groups to achieve this conversion. This study shows that O-tethered 1,6-enynes carrying a strained cycloalkane at the propargylic position could undergo a cyclopropanation/ring expansion cascade reaction. The author employed this rearrangement as the starting point in the design of a new macro cycle synthesis. The next part of the thesis focuses on the cycloisomerization of diynes involving as the first step of the process the rearrangement of one alkyne partner into an allene thanks to a gold-catalyzed 1,3-shift of a propargylic ester. The thesis discloses a new cycloisomerization pattern featuring a 1,5-carbonyl transfer, giving rise to unprecedented cross-conjugated diketones. In the final part of the research, Simmoneau investigates the gold-catalyzed cycloisomerization mechanism of 1,6-enynes and questions the intermediacy of gold acetylides. By |
| 出版日期 | Book 2014 |
| 关键词 | Acetylides; Cycloisomerization Reactions; Diynes; Enynes; Gold |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-06707-0 |
| isbn_softcover | 978-3-319-36097-3 |
| isbn_ebook | 978-3-319-06707-0Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer International Publishing Switzerland 2014 |
发表于 2025-3-21 19:01:52
