Titlebook: Glycolipids; Methods and Protocol Kazuya Kabayama,Jin-ichi Inokuchi Book 2023 The Editor(s) (if applicable) and The Author(s), under exclus

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Single-Molecule Imaging of Ganglioside Probes in Living Cell Plasma Membranes,arcely been investigated in living cells because of the lack of fluorescent probes that behave like their parental molecules. Recently, fluorescent ganglioside probes that mimic native ganglioside behaviors have been developed. In this chapter, I discuss the recent advances in research related to th

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https://doi.org/10.1007/978-3-662-25442-4ognize α-galactosylceramide (α-GalCer) and synthetic derivatives presented by CD1d molecules and secrete large amounts of cytokines that modulate immune functions. Some iNKT cell ligands induce distinct reactions biased toward either Th1 or Th2 immune responses, while others show mixed responses. We

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https://doi.org/10.1007/978-3-662-01558-2and in some cases have been used as adjuvants. Despite this abundant basic knowledge, the identities of the host immune receptors for mycobacterial lipids have long been elusive (Ishikawa et al., Trends Immunol 38:66–76, 2017). We describe the method of how to isolate glycolipids from microorganisms

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Die Differentialdiagnose des Kopfschmerzes, thus potential to act as adjuvants. However, canonical LPS acts as an endotoxin by hyperstimulating the immune response. Therefore, it is necessary to structurally modify LPS and lipid A to minimize toxicity while maintaining adjuvant effects for use as vaccine adjuvants. Various studies have focus

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Die Differentialdiagnose des Kopfschmerzes,ose with the phosphate group of phosphatidic acid (18:0, 20:0). Selective in situ activation of the anomeric center of .-glucose by 2-chloro-1,3-dimethylimidazolinium chloride (DMC) in aqueous media allows the omission of protecting groups while furnishing the required ß-phosphate linkage with high

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https://doi.org/10.1007/978-3-662-28492-6 A chemical biology approach using exogenously added glycolipid probes would be promising, but the possibility of cleavage by cellular glycohydrolases complicates the interpretation of results. Thus, there is a need for non-hydolyzable analogues. In the present study, we designed and synthesized GM3