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Titlebook: Glycoimmunology in Xenotransplantation; Cheorl-Ho Kim Book 2024 The Editor(s) (if applicable) and The Author(s), under exclusive license t

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Classification of Rejection in Host Recipients in Xenotransplantation, carbohydrate antigens different from interspecies and different species is the first and the crucial step because cell surfaced carbohydrates are biosynthesized by diverse and various glycosyltransferases. They are bound by preformed natural Abs or de novo biosynthesized Abs. They are subjects of t
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,Non-α1,3Gal Carbohydrate Antigenic Epitopes, xenografts. However, non-α1,3Gal Abs can induce graft-injured damages to cells in both vascularized organs and tissues. Transplanted xenografts induce production of non-α1,3Gal-specific Abs in the hosts. Likely to the human allograft rejection, the anti-non-α1,3Gal Abs control survivals of xenograf
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Delayed Rejection of Xenograft (DRX), delayed rejection is similar to the HR in its course and process. Human NK cells and CTLs are the major actors of delayed xenograft rejection (DRX) by cell mediation, but the DRX event is still in question [2]. DC is a regulator in anti-pig T-cell responses of human [2, 3]. The plasticity of DCs pr
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Blood Coagulation as Coagulation Dysregulation,are prerequisite in the pig-to-human or pig-to-primate xenotransplantation. Pig xenografts promote intensive thrombotic response of human blood, although pharmacological interventions and genetic targeting approaches have been made. To reduce acute thrombosis, human thromboregulatory genes have been
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