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Titlebook: Glycoimmunology 2; John S. Axford Book 1998 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+B

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书目名称Glycoimmunology 2
编辑John S. Axford
视频video
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Glycoimmunology 2;  John S. Axford Book 1998 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+B
描述The Jenner International Glycoimmunology Meetings have charted the rapid devel­ opment of glycobiology within the field of inflammation. In less than a decade, the science has grown from basically being involved in carbohydrate analysis to the understanding of how sugars are associated with inflammation and how they have potential as anti­ inflammatory therapeutics. The 4th Jenner International Glycoimmunology Meeting was re­ cently held in Loutraki, Greece, and set the scene for what promises to be an exciting future for the speciality. Discussion reflected the rapid advances glycobiology is making and ranged from the basic biochemistry of carbohydrate physiology to therapeutic trials utilizing synthetic sugars designed to block inflammatory responses. The meeting is summarized in considerable detail in this book which will provide the interested scientist and clinician with the essential up-to-date facts within the field of glyco­ immunology. Acknowledgments Many people have been involved in ensuring the success of the Jenner Glycoimmu­ nology Meetings but none more so than my secretary Susan Henderson who has borne the brunt of all four meetings and is currently preparing for th
出版日期Book 1998
关键词Oligosaccharid; Polysaccharid; biochemistry; development; infections; physiology; proteins; tissue
版次1
doihttps://doi.org/10.1007/978-1-4615-5383-0
isbn_softcover978-1-4613-7457-2
isbn_ebook978-1-4615-5383-0Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
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Biosynthesis of Sulfated L-Selectin Ligands in Human High Endothelial Venules (HEV)rate, a selective inhibitor of the synthesis of the high energy donor of sulfate, PAPS (3′-phosphoadénosine 5′-phosphosulfate), had previously revealed that PAPS synthesis is required for sulfation of HEV ligands and recognition by L-selectin. Therefore, we screened an HEV cDNA library in order to i
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Endothelial Sialyl Lewis X as a Crucial Glycan Decoration on L-Selectin Ligandsd/or sulfated sLex, respectively.. L-selectin was first characterized to guide lymphocyte traffic to lymph nodes and to sites of inflammation.. Today it is also known to participate in the rolling of leukocytes on vascular endothelium.. The two other members of selectin adhesion molecule family, E-
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Role of Lectin-Glycoconjugate Recognitions in Cell-Cell Interactions Leading to Tissue Invasiondothelial cell. This indicates the role of the endothelium which will be described here. Indeed, using high endothelial cell lines immortalized by us, we could demonstrate that endothelium of microcapillaries is characterized by its tissue-specific properties although with a high microenvironment de
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Cytokine and Protease Glycosylation as a Regulatory Mechanism in Inflammation and Autoimmunity of cytokines possess lectin-like functions and may thus interact with carbohydrates of the host or parasites. These intermolecular interactions influence for instance the compartmentalisation, the cell- and tissue-specific distribution and the pharmacokinetics of cytokines and proteinases. Attempts
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https://doi.org/10.1007/978-3-8348-9467-0rate, a selective inhibitor of the synthesis of the high energy donor of sulfate, PAPS (3′-phosphoadénosine 5′-phosphosulfate), had previously revealed that PAPS synthesis is required for sulfation of HEV ligands and recognition by L-selectin. Therefore, we screened an HEV cDNA library in order to i
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