Titlebook: Glycobiology of the Nervous System; Cara-Lynne Schengrund,Robert K. Yu Book 2023Latest edition The Editor(s) (if applicable) and The Autho

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Chemistry and Function of Glycosaminoglycans in the Nervous System,phogens, guidance molecules, survival factors, and other extracellular and cell-surface components. These interactions are often critical to the basic developmental processes of cellular proliferation and differentiation, as well as to both the onset of disease sequelae and prevention of disease pro

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Structural Analysis of Oligosaccharides and Glycoconjugates Using NMR,e targets for various amyloidogenic proteins associated with neurodegenerative disorders. To better understand the molecular mechanisms underlying these biological phenomena, atomic views are essential to delineate dynamic biomolecular interactions. Nuclear magnetic resonance (NMR) spectroscopy prov

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Glycans and Carbohydrate-Binding/Transforming Proteins in Axon Physiology,atodendritic domain to receive and integrate input signals while the axon is responsible for the propagation and transmission of the output signal. However, the axon must perform different functions throughout development before being fully functional for the transmission of information in the form

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Neurological Consequences of Congenital Disorders of Glycosylation,gical presentation of symptoms are summarized. Then, the occurrence of various neurological constellation of abnormalities (for example: epilepsy, brain anomalies on neuroimaging, ataxia, stroke-like episodes, autistic features) in different CDG types are discussed followed by data on possible bioma

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Brain O-GlcNAcylation: From Molecular Mechanisms to Clinical Phenotype, not further elongated but exists as a monosaccharide that can be rapidly added or removed. Thousands of proteins involved in gene transcription, protein translation and degradation as well as the regulation of signal transduction contain O-GlcNAc. Brain is one of the tissues where O-GlcNAc is the m

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Neuronal Ganglioside and Glycosphingolipid (GSL) Metabolism and Disease,ave a role in intercellular communication, serving as versatile biochemical signals (Kaltner et al, Biochem J 476(18):2623–2655, 2019) and in many cellular pathways. Anionic GSLs, the sialic acid containing gangliosides (GGs), are essential constituents of neuronal cell surfaces, whereas anionic sul

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Functional Impairment of the Nervous System with Glycolipid Deficiencies,ally burdens their family and society. It is difficult to achieve functional recovery for the damaged central nervous system (CNS) because of its limited ability to regenerate. Glycosphingolipids (GSLs) are abundant in the CNS and are known to play essential roles in cell-cell recognition, adhesion,