Titlebook: Glycobiology of Innate Immunology; Cheorl-Ho Kim Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive license to Spr

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Dendritic Cells (DCs) in Innate Immunity,ted for biological signal transduction. During the past 3 decades since 1985, the huge clarification of such primary defense system has been made. Once activation of the innate immunity is performed, adaptive immune system is operated by highly compromised and specific T-cell and B-cell receptors. T

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Glycan Biosynthesis in Eukaryotes, survival. Hence, any concept to explain the future unidirectional evolution is required in the biotic and abiotic environments. Then, the appropriate field has been raised from the dawn to create a link between water and hydrophilic environments, terming of “glycans” as molecules and “glycobiology”

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Pathogen-Host Infection Via Glycan Recognition and Interaction,ion of complement pathways. Oligosaccharide structures of cell surface and soluble glycans encode complex information. Like the stepwise recognition, cellular information is being decoded by carbohydrate-binding molecules, and these carbohydrates regulate the interaction between cells and cells or i

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Innate Immunity Via Glycan-Binding Lectin Receptors,ia. Innate immunity system represents our first host defense line where the innate pattern recognition receptors/molecules (PRRs/PRMs) encounter, recognize, and bind conserved motifs of microbial invaders or PAMPs. Therefore, the PRRs/PRMs function as the initiator of innate immunity to microbial in

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C-Type Lectin (C-Type Lectin Receptor),ostatic regulation, recognizing self-antigens to allow tolerance from the tissue environment. Therefore, one question is how the nature of the recognized antigens takes the balance between immunity and tolerance. CLRs expressed on DCs substantially recognize and bind glycosylated self-antigens and p

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DC-SIGNs,immune DC-SIGN receptor is also called CD209 and discovered over two decades ago. It recognizes a broad ligand structure of pathogen-derived patterns and self-glycoproteins. DC-SIGN functions for intercellular adhesion, antigen uptake, and signaling, crucial for DCs, although most studies on DC-SIGN

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