Titlebook: Glycobiology and Medicine; John S. Axford (Director) Conference proceedings 2003 The Editor(s) (if applicable) and The Author(s), under ex

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onsistent with this finding, the binding of 2G12 to gp120 could be inhibited by monomeric mannose but not by other hexoses. The data presented here suggests that the most likely epitope for 2G12 is formed from a specific cluster of mannose residues on the outer face of gp120, with the other glycans

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https://doi.org/10.1007/978-3-031-14838-5s, ceramide-specific glucosyltransferase. The use of .-alkylated imino sugars to establish SRT as an alternative therapeutic strategy is described in cell culture and gene knockout mouse disease models. One imino sugar, .-butyl-DNJ (.B-DNJ) has been used in clinical trials for type 1 Gaucher disease

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A Sweet Coating—How Bacteria Deal with Sugarsconsiderable interest recently with improved understanding of a variety of infectious diseases and normal developmental and adult processes at mucosal surfaces throughout the body (Tannock, 1999). An important part of the recognition process includes the glycobiology of the host mucosal cells and th

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Remnant Epitopes Generate Autoimmunity: From Rheumatoid Arthritis and Multiple Sclerosis to DiabetesAlthough the etiology of these diseases is unknown, they have a number of cellular and molecular mechanisms in common. Pro-inflammatory cytokines, such as interleukin-1 (IL-1) and tumor necrosis factor (TNF), are upregulated and activate the inflammatory process. Chemokines recruit and activate leuk

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Endothelial Cell Glycosylation: Regulation and Modulation of Biological Processesnstration, by Gowans and Knight in 1964, that circulating leukocytes enter secondary lymphoid organs at specialized endothelial sites (Picker and Butcher, 1992), which was the starting point for many studies to understand specificity of cell homing. T memory lymphocytes were first shown to be able t

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Lectin Domains on Cytokines immune system. Several tenths calcium-dependent lectins (C-type lectins; Dodd and Drickamer, 2001; Drickamer, 1997) have been identified each endowed with a different carbohydrate-binding specificity. For example, L-selectin (Foxall ., 1992; Lasky, 1992) recognizes the 6′-sulphated sialyl-Lewis. ep