Titlebook: Geriatric Oncology; Martine Extermann Reference work 2020 Springer Nature Switzerland AG 2020 Geriatric Oncology.Cancer.Elderly.Biology of

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Healthcare Informatics and Technology in Managing the Older Cancer Patient technology will require more senior adults to accept innovative approaches to healthcare. To bridge this digital divide, improvements must be made in terms of usability, data collection, privacy, speed, volume, and cost. With the aid of developing technologies, patient-reported outcomes may also be

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Role of Cell Cycle Control, Checkpoints, and DNA Repair Mechanisms in Stem Cells and Changes with Agr alterations in them significantly contribute to the transformation process and the development of diseases, such as MDS and leukemia. The following chapter will provide a general overview of cell cycle control, checkpoint activity, and DNA repair mechanisms in hematopoietic and other adult stem ce

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Chronic Mechanistic Target of Rapamycin Inhibition: Preventing Cancer to Delay Aging or Vice Versa?tive dubbed “rapalogues,” are considered too dangerous for chronic human use for longevity extension or cancer prevention. Nonetheless, these data raise the interesting possibility that a pharmacologic intervention to suppress mTOR, or more specifically mTORC1, could prolong lifespan or healthspan i

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Aging of Natural Killer Cells in Acute Myeloid Leukemiadults with a median age at diagnosis usually over 65 years old. NK cells in AML patients show a reduced expression of several activating receptors that impair NK cell function. Low level of expression of activating receptors such as NKp46 has been correlated with disease progression and patient surv

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Hematopoietic Stem Cell Aging and Malignant Hemopathiesation. However, at present our understanding of the process of aging is far from complete, and many open questions are currently under investigation. This chapter will focus on the complex multistep interplay between aging and the higher incidence of malignant hemopathies.

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Normal and Abnormal Aging (General Perspective for the Oncologist)hallenge overwhelms them, that is frailty. Additionally, aging can modify the impact, presentation, and natural history of any illness. This is because the substrate, the aging person, more than the disease pathophysiology, has been modified. In any given person, the system where the reserves are th

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Respiratory Organ Aging and Cancerthe leading cancer-related cause of death in the world. Most lung cancer in the USA is attributable to smoking. Globally, indoor air pollution is also a significant risk factor. Approximately 85% of lung cancer is non-small cell lung cancer (NSCLC), and adenocarcinoma is the predominant histologic t