Titlebook: Geriatric Oncology; Martine Extermann Reference work 2020 Springer Nature Switzerland AG 2020 Geriatric Oncology.Cancer.Elderly.Biology of

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Aging of Natural Killer Cells in Acute Myeloid Leukemia immune system function associated with aging. Natural killer (NK) cells are innate lymphoid cells specialized in killing tumor cells as well as virus-infected cells without the requirement of prior sensitization. NK cells are also involved in regulating immune function as they produce several cytok

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Hematopoietic Stem Cell Aging and Malignant Hemopathies extensively studied; cellular senescence, a protective mechanism in response to DNA damage, can induce permanent growth arrest and resistance to apoptosis. Chronological age also favors the accumulation of genetic and epigenetic changes that are important contributing factors in the complex pathoge

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Mitochondria, Oxidative Stress, Cancer, and Aging take place. Although ROS are an inevitable by-products of respiration, they do not necessarily have detrimental effects; low doses of ROS can have beneficial effects on cells, and their production can be finely regulated in mitochondria. Increasing ROS levels and products of the oxidative stress, w

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Normal and Abnormal Aging (General Perspective for the Oncologist)nged state, at homeostasis, age-related decrements in function from these changes are few in part because reserves are used to maintain homeostasis. When challenged, whether by diseases, environment, medications, etc., those age-related changes become apparent. These changes lead to increased vulner

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Respiratory Organ Aging and Cancerg aging may mimic obstructive and restrictive lung diseases. Lung parenchyma loses elasticity via alveolar wall and mesenchymal degradation and distortion, similar to emphysema. Muscles of respiration become sarcopenic and weaken, while the thorax contorts due to osteoporotic vertebral fractures, al

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Digestive Organ Aging and Cancer incidence above 75 years, and diagnosis in the elderly is done at more advanced stages..Management is complex with intensive treatments combining all available anticancer modalities of treatment depending on stage: major surgery, radiotherapy, chemotherapy, radio-chemotherapy, targeted therapy, etc

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https://doi.org/10.1007/978-3-319-57415-8Geriatric Oncology; Cancer; Elderly; Biology of Aging and Cancer; Comorbidity; Treatment Decision Making

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