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Titlebook: Genomics-Driven Healthcare; Trends in Disease Pr Yashwant Pathak Book 2018 Springer Nature Singapore Pte Ltd. 2018 Drug delivery.Drug disco

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发表于 2025-3-21 16:20:21 | 显示全部楼层 |阅读模式
书目名称Genomics-Driven Healthcare
副标题Trends in Disease Pr
编辑Yashwant Pathak
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概述Outlines steps for translating functional genomics into rational therapeutics.Describes recent trends in understanding the influence of genomics in disease and disease prevention.Provides understandin
图书封面Titlebook: Genomics-Driven Healthcare; Trends in Disease Pr Yashwant Pathak Book 2018 Springer Nature Singapore Pte Ltd. 2018 Drug delivery.Drug disco
描述.This book evaluates trends arising in “-Omics” sciences in terms of their current and potential future application to therapeutic design and understanding of disease. Chapters consider the impact of pharmacogenomics and bioinformatics on drug development, as well as trends in genomics, as applied to understanding of neurodegenerative and lung disease, psychiatry and oncology..Following the genome studies released in early part of this century, the advent of the -Omics sciences (genomics and pharmacogenomics, proteomics, metabolomics, transcriptomics) has seen the expansion of a vast knowledgebase with utility in preventing and treating disease, and improving health for all. Bioinformatics and improved pharmacogenetic understanding forge a path for improved drug discovery and design methods accounting for differences in delivery and disposition across populations..
出版日期Book 2018
关键词Drug delivery; Drug discovery; Drug metabolism; Drug transporters; Functional genomics; Genomics-based ra
版次1
doihttps://doi.org/10.1007/978-981-10-7506-3
isbn_softcover978-981-13-3959-2
isbn_ebook978-981-10-7506-3
copyrightSpringer Nature Singapore Pte Ltd. 2018
The information of publication is updating

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https://doi.org/10.1007/978-3-658-25767-5velopment. In other disease states, research is only just beginning to identify genetic loci that could be responsible for development. This chapter is meant to answer the following question: how much of our health can we control, and what role does genetic variation play in disease development?
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https://doi.org/10.1007/978-3-662-29106-1can vary greatly in their levels of expression, protein folding, membrane localization, and transporter efficiencies [3, 13]. These phenotypic differences can ultimately result in major interindividual variabilities in response to identical drug molecules (i.e., pharmacokinetics (PK), pharmacodynami
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https://doi.org/10.1007/978-3-662-26353-2beling describing risk for adverse drug events, genotype-specific dosing, and/or variations in pharmacokinetic and pharmacodynamic parameters. For a select group of medications, such as codeine and clopidogrel, pharmacogenomic information may even be highlighted in a black box warning further emphas
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https://doi.org/10.1007/978-3-658-25380-6associated with variability in drug response. This review focuses on the genetic polymorphisms of phases I and II DMEs and their associations with drug responses. The drugs discussed in this review requiring a pharmacogenomic test before being prescribed includes efavirenz, voriconazole, clopidogrel
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Die Ausrüstung der textilen Warenal pollutants, where the World Health Organization (WHO) now uses the term “environmental burden of disease” to describe adverse effects of a man-made climate, ecosystem degradation, cumulative rise in pollutants, noise, and electromagnetic fields, etc. While epigenetic environmental triggers can al
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Curt Heidermanns,Inge Kirchner-Kühnt these mutations. In this chapter, Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS) are discussed in detail for their pathophysiology, etiology, and latest symptomatic and preventive treatment. In preventive treatment, the latest
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