| 书目名称 | Genomic Architecture of Schizophrenia Across Diverse Genetic Isolates |
| 副标题 | A Study of Dagestan |
| 编辑 | Kazima Bulayeva,Oleg Bulayev,Stephen Glatt |
| 视频video | |
| 概述 | This volume represents a fitting compilation of decades of labor to dissect the genetic underpinnings of mental disorders that aggregate in distinct ethnic isolates.The book presents power and the pro |
| 图书封面 |  |
| 描述 | This book presents a long-term study in genetic isolates of indigenous small ethnics of Dagestan, located in the North-East part of Caucasus in Russia. Dagestan is characterized by extreme cultural and linguistic differences in a small geographic area and contains 26 indigenous ethnic groups. According to archeological data these indigenous highland ethnics have been living in the same area for more than ten thousand years. Our long-term population-genetic study of Dagestan indigenous ethnic groups indicates their close relation to each other and suggests that they evolved from one common ancestralmeta-population. Dagestan has an extremely high genetic diversity between ethnic populations and a low genetic diversity within them. Such genetic isolates are exceptional resources for the detection of susceptibility genes for complex diseases because of the reduction in genetic and clinical heterogeneity. The founder effect and gene drift in these primary isolates may have caused aggregation of specific haplotypes with limited numbers of pathogenic alleles and loci in some isolates relative to others. The book presents a study in four ethnically and demographically diverse genetic isola |
| 出版日期 | Book 2016 |
| 关键词 | genetic isolates; genetic linkage analysis; population genetics; schizophrenia; susceptibility genes for |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-31964-3 |
| isbn_softcover | 978-3-319-81164-2 |
| isbn_ebook | 978-3-319-31964-3 |
| copyright | Springer International Publishing Switzerland 2016 |
发表于 2025-3-21 17:12:01
