Titlebook: Genome Editing in Biomedical Sciences; Geraldo A. Passos Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusive licens

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,Rektifikation in Füllkörpersäulen,ed to investigate the role of TFAM in mitochondrial mechanics and biogenesis as well as its correlation to mitochondrial disorders. Thus this chapter brings a summary of mitochondria function, dysfunction, the importance of . in the maintenance of mitochondria, and state of the art of gene editing tools involving TFAM and mtDNA.

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Long Non-coding RNAs and CRISPR-Cas Edition in Tumorigenesis,NA targeting in tumorigenesis and drug resistance. Additionally, we highlighted the perspectives and potential applications of CRISPR approaches to treat cancer, as an emerging and promising target therapy.

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Genome Editing for Engineering the Next Generation of Advanced Immune Cell Therapies,s between cancer cells and T cells further restrict the access to these therapies. Here, we described how cutting-edge genome editing approaches have been applied to unlock the full potential of these revolutionary therapies, thereby increasing therapeutic efficacy and patient accessibility.

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BILIO

Control of Bleeding in Uremic Patientssy way. In this chapter, we will briefly present the history behind the development of this innovative tool, how it emerged from a natural bacterial mechanism for antiviral defense, its key components (Cas9 endonuclease and single guide RNA), mode of action (DNA cleavage and repair via NHEJ or HDR),

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https://doi.org/10.1007/978-981-15-0516-4rch disciplines, with some of the main beneficiaries being the fields of medicine and life sciences. Genetically engineered mouse models (GEMMs), along with other model organisms, are fundamentally important research tools frequently utilised to enhance our understanding of pathophysiology and biolo

新陈代谢

Joanne M. McKeown,Catherine G. Finet the transcriptional and post-transcriptional levels. Due to their role in cell growth and differentiation, lncRNAs have emerged as an important biomarker in cancer diagnosis, prognosis, and targeted treatment. Recent studies have focused on elucidating lncRNA function during malignant transformati