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Titlebook: Genome Editing; Kursad Turksen Book 2016 Springer International Publishing Switzerland 2016 CRISPR.ESC.iPSC.nucleases.stem cells

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发表于 2025-3-21 19:39:12 | 显示全部楼层 |阅读模式
书目名称Genome Editing
编辑Kursad Turksen
视频video
概述Presents the state of the science for CRISPR-Cas9 an increasingly hot field.Will include chapters on current controversies and future directions.Chapter authors are leaders in their fields and present
图书封面Titlebook: Genome Editing;  Kursad Turksen Book 2016 Springer International Publishing Switzerland 2016 CRISPR.ESC.iPSC.nucleases.stem cells
描述This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of controversies and future directions..Genome Editing. is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemicaland biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way..
出版日期Book 2016
关键词CRISPR; ESC; iPSC; nucleases; stem cells
版次1
doihttps://doi.org/10.1007/978-3-319-34148-4
isbn_softcover978-3-319-81687-6
isbn_ebook978-3-319-34148-4
copyrightSpringer International Publishing Switzerland 2016
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发表于 2025-3-21 21:21:21 | 显示全部楼层
CRISPR/Cas9 Approaches to Investigate the Noncoding Genome,omologous recombination in murine ES cells. Unfortunately, the study of the noncoding fraction of the genome did not benefit from the same valuable resources. Nevertheless, increasing evidence of the relevance of this fraction of the vertebrate genome has been accumulated in the past years. Comprehe
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发表于 2025-3-22 07:47:50 | 显示全部楼层
CRISPR/Cas9 and the Paradigm Shift in Mouse Genome Manipulation Technologies,. CRISPR represents one of only a few radical and transformative shifts in transgenic technologies over the past 30 years. This chapter discusses the paradigm shift that CRISPR technology has brought about in the field of mouse genome editing.
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Developments in the Generation of Reporter Stem Cells,s in drug screening, basic developmental research, and potential therapeutic implementations. An emerging need in stem cell biology is efficient and homogeneous differentiation of stem cells into mature, specialized, functional cells..Reporter stem cell lines are valuable models that enable noninvas
发表于 2025-3-22 17:10:05 | 显示全部楼层
Current Status of Genome Editing in Cardiovascular Medicine,the Precision Medicine Initiative in January 2015, emerging technologies such as induced pluripotent stem cells (iPSCs) and genome editing are well positioned to provide powerful tools to correlate genotypes with phenotypes. These new technologies are helping to identify specific mutations associate
发表于 2025-3-22 22:37:38 | 显示全部楼层
Using CRISPR-Cas9 Genome Editing to Enhance Cell Based Therapies for the Treatment of Diabetes Mellng pancreatic β-cells for diabetes treatment. To generate these cells in vitro requires a complete understanding of the normal process of pancreas development: an objective greatly aided by CRISPR-Cas9 genome-editing technology. First identified as the adaptive immune system of bacteria, CRISPR-Cas9
发表于 2025-3-23 05:03:47 | 显示全部楼层
Genome Editing in the Retina: A Case Study in CRISPR for a Patient-Specific Autosomal Dominant Retintions. The eye is an ideal target for gene therapy due to its accessibility, ease of noninvasive monitoring, significant compartmentalization, immunoprivileged status, optical transparency, and the presence of a contralateral control. One of the first gene therapy clinical trials was conducted in t
发表于 2025-3-23 07:23:26 | 显示全部楼层
978-3-319-81687-6Springer International Publishing Switzerland 2016
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