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Titlebook: Genetics of the Mouse; Jean Louis Guénet,Fernando Benavides,Xavier Montag Book 2015 Springer-Verlag Berlin Heidelberg 2015 animal models.m

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发表于 2025-3-21 19:48:58 | 显示全部楼层 |阅读模式
书目名称Genetics of the Mouse
编辑Jean Louis Guénet,Fernando Benavides,Xavier Montag
视频video
概述First comprehensive and up-to-date overview on mouse genetics since the mid-nineties.Essential reading for scientists working in mouse research.Written by experienced geneticists.Includes supplementar
图书封面Titlebook: Genetics of the Mouse;  Jean Louis Guénet,Fernando Benavides,Xavier Montag Book 2015 Springer-Verlag Berlin Heidelberg 2015 animal models.m
描述.This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits.. .The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided. . .In short, this book offers an essential resource for all scientists who use or plan to use mice in their research..
出版日期Book 2015
关键词animal models; mouse genetics; mutagenesis; rodent genetics; trangenesis; Transgenic organisms; gene expre
版次1
doihttps://doi.org/10.1007/978-3-662-44287-6
isbn_softcover978-3-662-51016-2
isbn_ebook978-3-662-44287-6
copyrightSpringer-Verlag Berlin Heidelberg 2015
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发表于 2025-3-21 23:34:35 | 显示全部楼层
Basic Concepts of Reproductive Biology and Genetics,n overview concerning mouse reproductive biology and embryology. This topic is important because, nowadays, many experiments in genetics require the manipulation of embryos at different stages of development, either to study their phenotype or for the production of chimeras with other embryos or wit
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Cytogenetics, the advent of the chromosomal theory of heredity at the beginning of the twentieth century, when W.S. Sutton and T.H. Boveri (then T.H. Morgan) identified the chromosomes as the physical structures on which the genes were anchored (1902–1915).
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Gene Mapping,arching the appropriate database. In this context, a chapter devoted to gene mapping and genetic maps might appear somewhat outdated, not to say useless. However, we thought that it might be interesting to reconsider this subject for at least three reasons. The first is that gene mapping has been a
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The Different Categories of Genetically Standardized Populations of Laboratory Mice, Aside from a few coat color mutants, which were bred by fanciers as pets, the only animals available for experiments were “albino” mice. These mice were bred with no specific mating protocol and were, in most cases, genetically heterogeneous. At that time, and based on the experience of dog and hor
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