Titlebook: Genetics of Substance Use; Research and Clinica Michael M. Vanyukov Book 2022 Springer Nature Switzerland AG 2022 genetics.substance abuse.

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Psychological Antecedents and Correlates of Substance Use and Addictionn-normative socialization during childhood and adolescence predisposed by suboptimal . of psychological self-regulation, whereas . ensues from stressor-induced diminution of psychological self-regulation..Psychological self-regulation is the main vulnerability trait in both addiction variants. It is

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Family and Adoption Studies of Substance Usees provide important confirmatory and complementary data to the study of twins. Although non-twin family studies cannot disentangle the underlying sources of familial resemblance, they have made important contributions to the identification of intra- and extra-familial risk factors, how familial inf

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Linkage and Association Studies of Substance Use Disordersan diseases (e.g., hypertension, major depression, schizophrenia), this high heritability observed in twin studies represents a large genetic contribution to variation in risk for developing a substance use disorder. In an effort to discover those genes and genetic variants contributing to substance

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Epigenomic Studies of Substance Useabnormal neuronal and brain activity following acute and repeated drug exposures. Altered gene-expression patterns are found in reward-related brain regions of drug addicts and in animal models. These changes in gene expression are responsible for morphological and molecular abnormalities in reward-