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Titlebook: Genetics of Rare Autoimmune Diseases; Javier Martín,Francisco David Carmona Book 2019 Springer Nature Switzerland AG 2019 Genomics.Autoimm

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书目名称Genetics of Rare Autoimmune Diseases
编辑Javier Martín,Francisco David Carmona
视频video
概述Comprehensive overview of the genetic predisposition to rare autoimmune diseases.Includes relevant insights into the shared genetic component of autoimmunity.Written by renowned clinicians and researc
丛书名称Rare Diseases of the Immune System
图书封面Titlebook: Genetics of Rare Autoimmune Diseases;  Javier Martín,Francisco David Carmona Book 2019 Springer Nature Switzerland AG 2019 Genomics.Autoimm
描述.The main aim of this volume is to provide an updated overview of the genetic basis of a group of complex disorders that are considered rare individually, but show a relatively high prevalence on the whole in developed countries: the rare autoimmune diseases. These are chronic disorders that involve long and expensive treatments with considerable side effects that may dramatically reduce the quality of life of affected people. Therefore, shedding light into their pathologic mechanisms is a major concern given their growing social and economic awareness and impact...General sections include different chapters on single entities as systemic lupus and sclerosis, Behçet’s disease, Sjogren’s syndrome and polymiositis, and sections devoted to autoimmune vasculitis, hepatic autoimmune conditions, as well as those affecting the nervous system, and a concluding chapter in which the shared predisposition amongst all diseases is discussed. All the chapters are given a homogeneous scheme in which the authors explain the clinical singularities of every disease and report the recent breakthrough discoveries related to them, giving a critical interpretation and suggesting future perspectives. All
出版日期Book 2019
关键词Genomics; Autoimmunity; Biomarkers; Systemic sclerosis; Systemic Lupus Erythematosus; Behçet disease; Sjor
版次1
doihttps://doi.org/10.1007/978-3-030-03934-9
isbn_ebook978-3-030-03934-9Series ISSN 2282-6505 Series E-ISSN 2283-6403
issn_series 2282-6505
copyrightSpringer Nature Switzerland AG 2019
The information of publication is updating

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,Sjögren’s Syndrome,ons. Indeed, even though keratoconjunctivitis sicca, resulting from the involvement of lacrimal glands, and xerostomia, resulting from the involvement of salivary glands, are usually prominent, pSS presents as a multifaceted and systemic condition with a broad variety of clinical manifestations. The
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Giant Cell Arteritis,ic factors may affect its susceptibility and phenotypic expression. During the last decades, a large number of candidate gene studies explored the genetic component of GCA. However, most genetic associations were inconsistent due to reduced sample sizes and lack of replication in independent populat
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Takayasu Arteritis,udes a preponderance of risk in East Asian, South Asian, and South American populations, as well as familial aggregation of the disease. The most reproduced genetic association with Takayasu arteritis is with the HLA-B*52 allele, with additional associations in the HLA region described across many e
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Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis, and Autoimmune Hepatitis,langitis (PSC), and autoimmune hepatitis (AIH), are complex conditions in which both genetic and environmental factors may affect the hepatobiliary system. Until recently, risk HLA haplotypes were the only genetic factor identified in these diseases, which were insufficient to explain most of the di
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