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Titlebook: Genetics of Immunological Diseases; Beverly Mock,Michael Potter Conference proceedings 1988 The Editor(s) (if applicable) and The Author(s

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书目名称Genetics of Immunological Diseases
编辑Beverly Mock,Michael Potter
视频video
丛书名称Current Topics in Microbiology and Immunology
图书封面Titlebook: Genetics of Immunological Diseases;  Beverly Mock,Michael Potter Conference proceedings 1988 The Editor(s) (if applicable) and The Author(s
描述The development of innovative molecular techniques such as pulse-field gel electro­ phoresis, cDNA subtraction libraries and chromosome hopping libraries coupled with the increasing popularity in the prospect of sequencing mammalian genomes, has triggered a resurgence of interest in finding and characterizing genes that playa role in modifying immune processes and diseases. Genetically defined strains of mice (e. g. , inbred strains and recently derived stocks of wild mice) provide ideal models for examining the genetic control of diseases as a result of their syntenic relationship with man in genetic composition as well as linkage conserva­ tion. Due to the relative ease of producing a specific genotype via appropriate breeding schedules, murine models may provide the only hope for unravelling those complex disease processes under mUltigenic control. This issue of CTMI is a collection of papers on the characterization and mapping of genes involved in mutations and dysregulated immune responses which produce disease phenotypes. These papers were presented at a workshop which was devoted to examining reverse genetic approaches at localizing, cloning and characterizing genes involved
出版日期Conference proceedings 1988
关键词diseases; genetics; immune response; infectious disease
版次1
doihttps://doi.org/10.1007/978-3-642-50059-6
isbn_softcover978-3-642-50061-9
isbn_ebook978-3-642-50059-6Series ISSN 0070-217X Series E-ISSN 2196-9965
issn_series 0070-217X
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE
The information of publication is updating

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https://doi.org/10.1007/978-3-642-91355-6perations, the effects of interference must be assessed and, if significant, corrected for. Finally, in cases which do not allow unambiguous maps to be constructed, it is useful to know how much additional data must be gathered. In solving these problems, it is desirable that the data be used efficiently and that the analysis proceed rapidly.
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X-Chromosome Gene Order in Different , Species Crosses 1987a; Avner ., 1987b; Brockdorff ., 1987; Chamberlain ., 1987; Heilig ., 1987), utilizes naturally occurring polymorphisms at the level of the nucleotide sequence between inbred strains of mice and those derived from the wild species. and . (Brown, 1985; Guénet, this publication).
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Bayesian Multilocus Linkage Mappingperations, the effects of interference must be assessed and, if significant, corrected for. Finally, in cases which do not allow unambiguous maps to be constructed, it is useful to know how much additional data must be gathered. In solving these problems, it is desirable that the data be used efficiently and that the analysis proceed rapidly.
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