Titlebook: Genetics and Auditory Disorders; Bronya J. B. Keats,Richard R. Fay,Arthur N. Popper Book 2002 Springer Science+Business Media New York 200

清晰

Der Kampf um den verlorenen Tagusing spontaneous mouse models of mitochondrial hearing impairment, or direct investigation of the most likely biochemical pathways involved, may help not only in elucidating the pathophysiology between mtDNA mutations and hearing loss, but may also provide a paradigm for mitochondrial diseases in g

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Introduction and Overview: Genetics in Auditory Science and Clinical Audiology,

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Mapping and Cloning of Genes for Inherited Hearing Impairment,ssion, audiological configuration, etc.), the description of the phenotype should include documentation of the presence or absence of associated vestibular abnormalities, and/or neuroradiological findings in the inner ear. By this means, the results of the research findings will rapidly translate in

疯狂

Cytogenetics and Cochlear Expressed Sequence Tags (ESTs) for Identification of Genes Involved in Henslocation. The advantage would be that, if such a chromosome rearrangement were found, it would immediately suggest the location of the deafness gene..The cochlear ESTs and libraries that exist have been extremely helpful in understanding different aspects of the molecular biology of the inner ear.

手榴弹

Hearing Loss and Mitochondrial DNA Mutations: Clinical Implications and Biological Lessons,using spontaneous mouse models of mitochondrial hearing impairment, or direct investigation of the most likely biochemical pathways involved, may help not only in elucidating the pathophysiology between mtDNA mutations and hearing loss, but may also provide a paradigm for mitochondrial diseases in g

污点

Mice as Models for Human Hereditary Deafness,to fill the gap between human deafness and mouse models (Nolan et al. 2000). Large-scale, genome-wide mutagenesis programmes are starting in other countries too, including the US, so there will soon be many more mutants available. Deafness is one of the most heterogeneous diseases known in humans, a

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