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Titlebook: Genetics and Molecular Biology of Anaerobic Bacteria; Madaleine Sebald Book 1993 Springer Science+Business Media New York 1993 Biosynthese

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Mutations, this interest was directed toward such modified properties as increased formation of metabolites, e.g., neutral solvents of . or hyperproduc-tion of clostridial toxins for vaccines. Investigators often faced unwanted losses in properties of laboratory strains in which the mechanism may have been re
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Conjugative Gene Transfer in Clostridia, transfer in Clostridia; it was also one of the earliest reports of conjugative gene transfer between gram-positive bacteria. During the past decade, several conjugative elements, both plasmids and transposons, have been identified in the predominantly pathogenic, amino acid-fermenting Clostridia. A
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Antibiotic Resistance Determinants of ,,. In rich media it grows rapidly and ferments sugars to produce H. and CO., the evolution of which helps to maintain an anerobic environment. The organism is aerotolerant; it is capable of surviving for extended periods of time in the presence of O.. . is of considerable clinical significance as the
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Genetics and Molecular Biology of Antibiotic Resistance in ,: General and Specific Overview,70s, although its capability to produce a cytotoxin was known. Pseudomembranous colitis (PMC) has also been known for a long time; Finney (1893) first described it as a complication of abdominal surgery. PMC was very rare until 1952 when, after the first report of PMC following antimicrobial therapy
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Genetics and Molecular Biology of Chloramphenicol Acetyltransferase of ,,ainst a variety of . species. Its mode of action is to inhibit the peptidyl-transferase center of procaryotic ribosomes (Hahn, 1983). Resistance of anaerobic bacteria to chloramphenicol can result from enzymatic inactivation of the antibiotic by either reduction or O-acetylation.
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The Role of Bacteriophages and Plasmids in the Production of Toxins and Other Biologically Active S. are recognized specifically for their ability to produce neurotoxins that are responsible for wound, toxicoinfectious, and food-borne forms of botulism in man and animals. Members of . do not produce neurotoxins, but they produce other lethal toxins and biologically active substances active in gas
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Gene Cloning and Organization of the Alpha-Toxin of ,, of breaking down organic materials to yield essential nutrients (McDonel, 1986). It is not clear why many of these enzymes are also potent toxins. At least 12 toxic proteins have been shown to be produced by C. . (McDonel, 1986), but most are considered minor toxins of questionable significance in
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