| 书目名称 | Genetic Variation | | 副标题 | Methods and Protocol | | 编辑 | Michael R. Barnes,Gerome Breen | | 视频video | | | 概述 | Division of Psychological Medicine and Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, London, UK.Includes supplementary material: | | 丛书名称 | Methods in Molecular Biology | | 图书封面 |  | | 描述 | “Your genome is an email attachment” What a difference a few years can make? In 2001, to a global fanfare, the completion of the frst draft sequence of the human genome was announced. This had been a Herculean effort, involving thousands of researchers and millions of dollars. Today, a project to re-sequence 1,000 genomes is well underway, and within a year or two, your own “personal genome” is likely to be available for a few thousand pounds, a price that will undoubtedly decrease further. We are fast approaching the day when your genome will be available as an email attachment (about 4 Mb). The key to this feat is the fact that any two human genomes are more than 99% identical, so rather than representing every base, there is really only a requirement to store the 1% of variable sequence judged against a common reference genome. This brings us directly to the focus of this edition of Methods in Molecular Biology, Genetic Variation. The human genome was once the focus of biology, but now individual genome var- tion is taking the center stage. This new focus on individual variation ultimately democ- tizes biology, offering individuals insight into their own phenotype. But these adv | | 出版日期 | Book 2010 | | 关键词 | Bioinformatics; Copy number variation (CNVs); DNA; Genome sequencing; Human phenotypes; Personalized medi | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-60327-367-1 | | isbn_softcover | 978-1-62703-826-3 | | isbn_ebook | 978-1-60327-367-1Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Humana Press 2010 |
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发表于 2025-3-21 16:24:25
