Titlebook: Genetic Models of Immune and Inflammatory Diseases; Abul K. Abbas,Richard A. Flavell Book 1996 Springer-Verlag New York, Inc. 1996 Antigen

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B7-Deficient Mice Reveal an Alternative Functional CTLA-4 Counterreceptors pathway is more complex than previously thought. Analysis of the B7- 1-deficient mouse strain revealed the existence of additional functional CTLA4 counterreceptor(s) and indicated that despite the powerful co- stimulatory effects of B7-1 in vitro, in vivo the absence of B7-1 resulted in only a pa

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Cytokine Transgenic Mice and Autoimmunitye or prevent immunological reactions in the target tissue. Immunoregulation by the counterbalance between immunostimulatory and immunoinhibitory cytokines appears to be important in the maintenance of immune tolerance, given the existence of potential autoreactive cells escaping from thymic censorsh

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https://doi.org/10.1007/978-3-8349-8971-0nes mapping in the . (MHC), involves the invasion of the islets of Langerhans and the destruction of pancreatic β cells by T lymphocytes, and results in glucosuria and ketoacidosis. The T lymphocytes consist of a mixture of CD4 and CD8 T cells, and adoptive transfer studies have confirmed the role of these two cell types in β-cell destruction (1).

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