Titlebook: Genetic Instability and Tumorigenesis; Michael B. Kastan Book 1997 The Editor(s) (if applicable) and The Author(s), under exclusive licens

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Role of DNA Excision Repair Gene Defects in the Etiology of Cancer, of human cancers. Mutations in genes important for normal cellular functions and growth properties, including many proto-oncogenes and tumor suppressor genes, may result from spontaneous or environmentally induced alterations in DNA and contribute directly to the multistage process leading to malig

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arthrodesis

Utho Creusen,Gordon Müller-Seitzn nucleotide base pairs, and each daughter cell must receive the correct number of the 46 chromosomes into which the instruction book of life is parceled. The challenging task of accurate DNA replication and distribution must be accomplished while the cell is under constant attack by forces that damage DNA.

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Book 1997k about genetic diseases, we think about inheriting one or two abnormal genes from our parents and these gene abnormalities confer the disease phenotype. In contrast, in the majority of cancers, no such inherited gene abnormalities can be identified (which does not mean that they do not exist) and t