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Titlebook: Genetic Consequences of Nucleotide Pool Imbalance; Frederick J. Serres Book 1985 Plenum Press, New York 1985 DNA.Nucleotide.enzyme.gene.ge

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书目名称Genetic Consequences of Nucleotide Pool Imbalance
编辑Frederick J. Serres
视频video
丛书名称Basic Life Sciences
图书封面Titlebook: Genetic Consequences of Nucleotide Pool Imbalance;  Frederick J. Serres Book 1985 Plenum Press, New York 1985 DNA.Nucleotide.enzyme.gene.ge
描述This book is concerned with the genetic consequences of nu­ cleotide pool imbalance. There are a number of ways in which this state can be achieved and the majority of papers in this volume de­ scribe the effects of nucleotide pool imbalance on DNA replication and repair, and the induction of gene mutations in various organisms. This book grew out of a Conference on "Genetic Consequences of Nu­ cleotide Pool Imbalance" which was held at the National Institute of Environmental Health Sciences on May 9-11, 1983. The Organizing Com­ mittee consisted of Drs. Diana Anderson (BIBRA), Robert Haynes (York University), Bernard Kunz (NIEHS), Barry Glickman (NIEHS), and Frederick J. de Serres (NIEHS), Chairman. The meeting was org- ized by the staff of the Office of the Associate Director for Genetics and was financed solely by the National Institute of Environmental Health Sciences. Frederick J. de Serres, Ph.D. Associate Director for Genetics v CONTENTS SECTION I. INTRODUCTION Molecular Mechanisms in Genetic Stability and Change: 1 The Role of Deoxyribonucleotide Pool Balance •••••• Robert H. Haynes SECTION II. NUCLEOTIDE METABOLISM 25 Metabolic Effects of Poly(ADP-ribose) Inhibitors ••••••
出版日期Book 1985
关键词DNA; Nucleotide; enzyme; gene; genetics; metabolism; molecular mechanisms; mutation; replication
版次1
doihttps://doi.org/10.1007/978-1-4613-2449-2
isbn_softcover978-1-4612-9488-7
isbn_ebook978-1-4613-2449-2
copyrightPlenum Press, New York 1985
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Thymineless Mutagenesis in Bacteriaest that removal of uracil from DNA plays a role in the generation of frameshift mutations by thymine deprivation. A model that involves nucleotide misincorporation into DNA and induction of error-prone repair functions in response to thymine starvation is proposed to account for these findings.
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Thymineless Death and Genetic Events in Mammalian Cellsortions of the genome and in some specific manners in contrast to those induced by X-ray, which occurred rather randomly. Cycloheximide blocked thymineless death and accumulation of the double stranded DNA fragments in parallel. The double strand breaks induced by thymidine starvation were not repai
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Induction of Mitochondrial Mutations in Human Cells by Methotrexatedium. This mitochondrial specific mutagenesis can also be achieved using the thymidylate synthetase inhibitor, 5-fluorodeoxyuridine further implicating thymidylate pools as the mediator of this effect. During the course of exposure to 10. M MTX the thymidine kinase deficient HeLa BU25 cell line exhi
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Digitalisierung in Unternehmen,he fidelity of DNA synthesis . as a function of the relative concentration of nucleotides. We will also consider recent studies suggesting that DNA-damaging agents alter nucleotide metabolism in cells.
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