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Titlebook: General Pharmacology; A. J. Clark Book 1937 Verlag von Julius Springer 1937 Acetylcholin.Hormone.Insulin.Nicotin.Pharmakologie.alkaloids.c

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Concentration-action Relations II,ion of narcotics on cells. Unfortunately any explanation involves assumptions regarding the nature of the cell membrane, which is a controversial matter and since hypotheses regarding the nature of the cell membrane are to a large extent based on the action of narcotics, the subject is a difficult one to discuss.
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Quantitative Aspects of Drug Antagonism and of Drug Synergism, altered by the administration of one drug, then this change will probably alter the sensitivity of the organism to other drugs. According to this view almost any pair of drugs are likely to show either antagonism or synergism to a greater or less extent.
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Individual Variation of Response to Drugs,lasses, those responding and those which fail to respond. In some cases the individual variation in response to drugs is distributed according to the normal curve of error, but in many cases skew distributions occur which cover very wide ranges of concentration.
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Introduction,actually developed in a narrower field because its chief original aim was to provide a scientific basis for therapeutics. This study required as its basis an adequate knowledge of the functions of the normal organism (physiology) and the derangements of these by disease (pathology), hence pharmacolo
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Methods of General Pharmacology,oach is to apply the methods used in physical chemistry, but any such attempt at once reveals the following fundamental difficulties. In the first place the simplest cell is a far more complex structure than any system studied by physical chemists. This complexity greatly reduces the significance of
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General Characteristics of the Cell-Drug System,2 and 3. The measurements in these three tables are, for convenience, given in different units, but these can readily be transposed. (1 micron = 1000 millimicra, 1 mμ = 10 A., 1 cubic micron = 10. cubic millimicra and 1 cu.mμ = 1000 cubic A.)
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