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Titlebook: General Pharmacology; A. J. Clark Book 1937 Springer-Verlag Berlin Heidelberg 1937 heavy metals.metals.temperature.therapy.tissue

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Action of Various Enzyme Poisons in vitro and in vivo,There are a number of common enzyme poisons which have been studied extensively and which are of interest either because they show special forms of concentration-action relations or because they permit the comparison of the action of enzyme poisons on purified enzymes and on the living cell.
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Concentration-action Relations I,The following three chapters (8, 9 and 10) give an account of the manner in which the actions of drugs on cells can be classified according to the relations observed between the concentration of the drug and the action produced. This relation has been chosen as the basis of classification for the following reasons.
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The Rate of Action of Drugs on Cells,The rate of response of a tissue to the action of a drug can be studied in two way:
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Automatic Distribution in Pangaeaactually developed in a narrower field because its chief original aim was to provide a scientific basis for therapeutics. This study required as its basis an adequate knowledge of the functions of the normal organism (physiology) and the derangements of these by disease (pathology), hence pharmacolo
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rried out by means of proteins carrying active groups and since these proteins are acted upon by many drugs, the study of the reactions between active proteins and drugs provides valuable information regarding the more complex problem of the action of drugs on cells.
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Communications Standard Dictionaryovides a particularly favourable introduction to the study of the action of drugs on cell functions. Moreover some important drugs are known to produce their pharmacological action by inactivating either enzymes or co-enzymes (e.g. arsenious acid, physostigmine, iodoacetic acid).
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