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Titlebook: Gene and Cellular Immunotherapy for Cancer; Book 2022

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Crimean – Congo Hemorrhagic Fevernimized via appropriate and timely interventions described herein such that the majority can be treated safely. Additional issues including prolonged cytopenias, on-target but off-tissue B-cell cytotoxicity and resulting aplasia and hypogammaglobulinemia, the theoretical development of replication-c
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Clinical Guide to Exposure Therapy using mouse models beginning in the first half of the twentieth century led to pioneering work carried out by the group led by Steven A. Rosenberg at the Surgery Branch of the National Cancer Institute (NCI) that developed adoptive cellular therapy (ACT) with tumor infiltrating lymphocytes (TIL). N
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Combination Therapeutics with CAR-T Cell Therapyer strategies involve combining existing CAR-T therapies with other treatment modalities. In this chapter, we will focus on combination strategies that are currently being used and/or are under exploration. We will first discuss strategies used to increase CAR-T effectiveness through combination wit
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Manufacturing of CAR-T Cells: The Assembly Linecell manufacturing platforms are highlighted in the context of recent clinical trials. Quality requirement and quality control assays enabling the release of clinical CAR-T cell products for infusion are also underscored. The broadening of the scope of CAR-T cell applications beyond cancer therapies
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Navigating Regulations in Gene and Cell Immunotherapyn’s severity and the unmet medical need. This chapter focuses on US Food and Drug Administration (FDA) regulatory considerations for human cellular immunotherapy products used for the treatment of cancer, including genetically-modified cellular immunotherapies.
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CAR-T Cell Complicationsnimized via appropriate and timely interventions described herein such that the majority can be treated safely. Additional issues including prolonged cytopenias, on-target but off-tissue B-cell cytotoxicity and resulting aplasia and hypogammaglobulinemia, the theoretical development of replication-c
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