| 书目名称 | Gene Therapy for HIV |
| 副标题 | From Inception to a |
| 编辑 | Gerhard Bauer,Joseph S. Anderson |
| 视频video | |
| 概述 | Contributors include scientists who developed the first clinical applications of stem-cell gene therapy for HIV.Outlines a path for a possible functional cure for HIV.Comprises a thorough and methodic |
| 丛书名称 | SpringerBriefs in Biochemistry and Molecular Biology |
| 图书封面 |  |
| 描述 | .This Brief describes the concept and realization of gene therapy for HIV from the unique historic perspective and insight of two pioneers of the clinical applications of stem cell gene therapy for HIV..Gerhard Bauer applied ribozyme-anti-HIV and other vectors to manufacture clinical grade, HIV-resistant hematopoietic stem cells for the first patients that received stem cell gene therapy for HIV, including the first child in the world and the first fully marrow-ablated HIV infected patient. Joseph Anderson developed the most recent and most potent combination anti-HIV lentiviral vectors and pluripotent stem cell applications for HIV gene therapy and tested these in the appropriate in vitro and vivo models, paving the way for novel HIV gene therapy approaches to possibly cure patients..In .Gene Therapy for HIV., Bauer and Anderson discuss the unique aspects of this therapy, including its limitations and proper safety precautions and outline a path for a possible functional cure for HIV using stem cell gene therapy based on a cure already achieved with a bone marrow stem cell transplantation performed in Germany using donor stem cells with a naturally arising CCR5 mutation. In additi |
| 出版日期 | Book 2014 |
| 关键词 | Anti-HIV genes; CCR5 receptor knockout; Functional cure for HIV; Hematopoietic stem cells; Stem-cell gen |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4939-0434-1 |
| isbn_softcover | 978-1-4939-0433-4 |
| isbn_ebook | 978-1-4939-0434-1Series ISSN 2211-9353 Series E-ISSN 2211-9361 |
| issn_series | 2211-9353 |
| copyright | Gerhard Bauer and Joseph S. Anderson 2014 |
发表于 2025-3-21 17:53:38
