| 书目名称 | Gene Therapy for Cancer | | 编辑 | Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swis | | 视频video | | | 概述 | Vectors used in gene therapy for cancer.Characteristics and production methods of cancer gene vectors.Targets and specific approaches for the therapy of cancer.Clinical applications of cancer gene the | | 丛书名称 | Cancer Drug Discovery and Development | | 图书封面 |  | | 描述 | The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes. Unlike the treatment of genetic defects, where expr- sion of the corrected gene needs to be strong, permanent and, sometimes regulated, tactics to treat tumors can be based on temporary and | | 出版日期 | Book 2007 | | 关键词 | angiogenesis; apoptosis; cancer treatment; clinical trial; gene therapy; gene transfer; hematopoietic stem | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-59745-222-9 | | isbn_softcover | 978-1-61737-590-3 | | isbn_ebook | 978-1-59745-222-9Series ISSN 2196-9906 Series E-ISSN 2196-9914 | | issn_series | 2196-9906 | | copyright | Humana Press 2007 |
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发表于 2025-3-21 17:23:45
